Our study on cellular magnesium imbalance in drug induced liver injury is now in press (doi:10.1038/s41467-022-34262-0) in Nature Communications!

Acetaminophen overdose is one of the leading causes for acute liver failure. In this study, patients with acetaminophen-induced liver injury (AILI) were found to have abnormal serum magnesium levels and significantly elevated expression of Cyclin M4 (CNNM4), a protein that modulates cellular magnesium. Silencing of hepatic Cnnm4 in mice with acetaminophen overdose restored magnesium levels, ameliorating mitochondrial function and ER stress in affected hepatocytes. The study suggests a possible new therapeutic avenue for the treatment of AILI and further underscores the importance of magnesium balance in supporting liver health.

The research was conducted by an international team of scientists from Spain, Canada, Germany, and USA.