Author: Daniela

Restoring magnesium balance in the liver protects against drug-induced liver injury

 

Our study on cellular magnesium imbalance in drug induced liver injury is now in press (doi:10.1038/s41467-022-34262-0) in Nature Communications!

Acetaminophen overdose is one of the leading causes for acute liver failure. In this study, patients with acetaminophen-induced liver injury (AILI) were found to have abnormal serum magnesium levels and significantly elevated expression of Cyclin M4 (CNNM4), a protein that modulates cellular magnesium. Silencing of hepatic Cnnm4 in mice with acetaminophen overdose restored magnesium levels, ameliorating mitochondrial function and ER stress in affected hepatocytes. The study suggests a possible new therapeutic avenue for the treatment of AILI and further underscores the importance of magnesium balance in supporting liver health.

The research was conducted by an international team of scientists from Spain, Canada, Germany, and USA.

Commencement 2022

 

Finally coming together in person to celebrate three years of Buccella group graduates.

Very proud of you, Drs. Michael Brady (PhD ’21), Brismar Pinto-Pacheco (PhD ’20), and Elsy El Khoury (PhD ’22)!

Volunteering as tree stewards in Washington Square

This Thanksgiving, we volunteered to be ‘tree stewards‘ in Washington Square!

The Buccella lab and members of the NYU Chemistry community spent an afternoon weeding, watering, and planting new vegetation for the Spring.

A big thank you to Elsy El Khoury for coordinating with the NYC Parks stewardship program. A great way to nurture physical and mental health while contributing to a greener, healthier neighborhood!

Georgina graduates with honors!

Georgina Dabdoub (CAS 2021) receives her B.S. degree in Chemistry with honors from NYU!

Georgina is the recipient of the NYU Chemistry Alumni Award presented for an outstanding record in chemistry, and of the Founders Day Award from the University. She will soon start work at AbbVie and then off to graduate school.

Congratulations and best of luck, Georgina!