Research

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Research Overview

Metal cations are essential for all forms of life, and disrupted metal homeostasis has been related to some of the major ailments affecting our modern society, including neurodegeneration, diabetes, immunodeficiency, and cancer.

Research in the Buccella laboratory focuses on the development and application of novel molecular tools and imaging strategies for the study of metal ions and metalloenzymes in vitro and in vivo, with the ultimate goal of garnering a better understanding of the mechanisms that regulate metal homeostasis at the cellular level and of the molecular basis for the connection between disrupted metal balance and disease.

Check back soon for updates on our current projects…